# Gecombineerde indices van ontsteking, triglyceriden en glucose correleren met sterfte bij afwijkende glycemiestatus

*geplaatst 2026-09-16 · Cholesterol · Diabetes research and clinical practice · doi 10.1016/j.diabres.2026.113541 · https://hartvaat.nl/2026/10/01/gecombineerde-indices-van-ontsteking-triglyceriden-en-glucose-correleren-met-ste/*

Een nationaal cohort van 13.867 volwassenen uit NHANES onderzocht de associatie van samengestelde indices (gebaseerd op CRP, triglyceriden, glucose en anthropometrie) met alle-oorzaak- en cardiovasculaire sterfte, gesplitst naar glycemiestatus. Bij deelnemers met abnormale glycemia waren de hazard ratios per standaarddeviatie voor de CTI-ABSI en CTI-WWI respectievelijk 1,21 en 1,43 voor alle-oorzaak-sterfte, en 1,43 en 1,49 voor cardiovasculaire sterfte. De indices verbeteren de voorspellende waarde naast klinische factoren slechts minimaal en tonen geen significante interactie met de glycemiestatus. De auteurs concluderen dat deze indices momenteel vooral als epidemiologische markers dienen en geen directe klinische toegevoegde waarde hebben.

## English: Associations of C-reactive protein-triglyceride glucose-related indices with mortality across glycemic states: a nationwide prospective cohort study.

A nationwide cohort of 13,867 adults from NHANES evaluated the association of composite inflammation-metabolic indices (integrating CRP, triglycerides, glucose, and anthropometrics) with all-cause and cardiovascular mortality across glycemic strata. Among participants with abnormal glycemia, hazard ratios per standard deviation for the CTI-ABSI and CTI-WWI were 1.21 and 1.43 for all-cause mortality, and 1.43 and 1.49 for cardiovascular mortality, respectively. These indices add minimal predictive value beyond standard clinical factors and show no significant interaction with glycemic status. The authors conclude that these markers remain primarily epidemiological tools without validated clinical utility for routine practice.

## Abstract (original, from the publication)

BACKGROUND: The associations and comparative discrimination of indices integrating inflammation, insulin resistance, and body shape within glycemic-status strata remain uncertain. METHODS: We included 13,867 adults from the 1999-2010 and 2015-2018 National Health and Nutrition Examination Survey. Complex-survey weighted Cox models evaluated CTI, CTI-BMI, CTI-BRI, CTI-WWI, CTI-ABSI, and CTI-WHtR continuously and by weighted quartiles in participants with normal glycemia, abnormal glycemia, or diabetes. Restricted cubic splines, time-dependent receiver operating characteristic curves, interaction tests, and sensitivity analyses were performed. RESULTS: During follow-up, 2,197 all-cause and 687 cardiovascular deaths occurred. Among participants with abnormal glycemia, the hazard ratios per weighted standard deviation for CTI-ABSI were 1.21 (95 % CI, 1.10-1.34) for all-cause mortality and 1.43 (95 % CI, 1.18-1.73) for cardiovascular mortality. Corresponding estimates for CTI-WWI were 1.19 (95 % CI, 1.07-1.33) and 1.49 (95 % CI, 1.20-1.85). CTI-ABSI and CTI-WWI had relatively higher single-marker AUCs in several analyses, but incremental improvements beyond clinical factors were small. Glycemic-status interactions were not statistically significant. CONCLUSIONS: Several CTI-related indices were associated with mortality within glycemic-status strata. However, the findings do not establish effect modification, group-specific applicability, or validated clinical utility. These indices should be considered epidemiological markers.

Auteurs: Junqi Liao, Jie Yang, Yuanyuan Zhao, Zhiquan Tang, Min Wang, Shuting Jiang, Mingming Fang, Hongquan Liu

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Bron: Diabetes research and clinical practice, https://doi.org/10.1016/j.diabres.2026.113541. Bijgewerkt 2026-09-10T00:53:44Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.