{"id":"2add356a3f15","type":"article","url":"https://hartvaat.nl/2026/10/01/neurogenieke-hart-syndromen-hersenen-hartas-en-praktische-classificatie/","title":"Neurogenieke hart syndromen: hersenen-hartas en praktische classificatie","title_en":"Neurogenic Cardiac Syndromes: Pathophysiology and Classification.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","internist"],"tags":[],"journal":"Heart failure clinics","doi":"10.1016/j.hfc.2026.07.006","source_url":"https://doi.org/10.1016/j.hfc.2026.07.006","authors":["Anil Sahin","Mehmet Birhan Yilmaz"],"significance":3,"published":"2026-09-18","source_date":"2026-10-01","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/wat-is-hartfalen/","https://hartvaat.nl/kennis/hartfalen/neurohormonale-activatie-bij-hartfalen/"],"congress":"","summary_en":"This review outlines neurogenic cardiac syndromes (NCS), where neurological injury or autonomic dysfunction triggers arrhythmias, hemodynamic instability, and heart failure. The authors detail the brain-heart axis, highlighting mechanisms such as sympathetic overactivation, vagal withdrawal, and endothelial dysfunction, and propose a practical classification framework for various NCS phenotypes. This structured approach aims to improve early recognition and guide multidisciplinary management in patients with overlapping neurological and cardiovascular conditions.","created":"2026-09-12T00:55:12Z","updated":"2026-09-12T00:55:12Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Dit overzicht beschrijft neurogenieke hart syndromen (NCS), waarbij neurologische schade of autonome dysfunctie leidt tot ritmestoornissen, hemodynamische instabiliteit en hartfalen. De auteurs schetsen de onderliggende hersenen-hartas, waaronder sympathische overactivatie, vagale terugval en endotheeldysfunctie, en stellen een praktisch classificatiekader voor verschillende NCS-fenotypen. Deze indeling kan cardiologen en internisten helpen bij het vroegtijdig herkennen en multidisciplinair managen van patiënten met een overlap tussen neurologische en cardiovasculaire aandoeningen.","abstract_original":"Neurogenic cardiac syndromes (NCS) encompass cardiac rhythm, functional, and hemodynamic abnormalities triggered or amplified by neurologic injury, autonomic dysfunction, or stress-related central nervous system activation. This article summarizes the brain-heart axis, shared mechanisms including sympathetic overactivation, vagal withdrawal, impaired heart rate variability and baroreflex sensitivity, neuroinflammation, endothelial dysfunction, and myocardial stunning, and proposes a practical classification framework. Acute brain injury-related, seizure-related, chronic autonomic failure-related, stress-related, and heart failure-associated NCS phenotypes are integrated to support earlier recognition, monitoring, and multidisciplinary management."}