# Plantaardig nitraat en nitriet verlagen hypertensierisico — Tehran Lipid and Glucose Study

*geplaatst 2026-09-30 · Preventie · Nutrition research (New York, N.Y.) · doi 10.1016/j.nutres.2026.07.010 · https://hartvaat.nl/2026/10/01/plantaardig-nitraat-en-nitriet-verlagen-hypertensierisico-tehran-lipid-and-gluco/*

In een prospectieve cohortstudie onder 1576 volwassenen uit de Tehran Lipid and Glucose Study werd de relatie onderzocht tussen de inname van nitraat en nitriet uit voeding en het ontstaan van hypertensie. Deelnemers in het hoogste kwartiel van de totale en plantaardige nitraatinname hadden een significant lager risico op hypertensie (HR respectievelijk 0,46 en 0,44), evenals voor plantaardig nitriet (HR 0,57). Dierlijke bronnen toonden geen beschermend effect. Deze bevindingen ondersteunen het advies om plantaardige voedingbronnen van nitraat en nitriet te stimuleren als onderdeel van primaire preventie van hoge bloeddruk.

## English: Source-specific dietary nitrate and nitrite intakes are differentially associated with the incidence of hypertension: Tehran Lipid and Glucose Study.

A prospective cohort study of 1,576 adults from the Tehran Lipid and Glucose Study examined the association between dietary nitrate and nitrite intake and incident hypertension. Participants in the highest quartile of total and plant-based nitrate intake had a significantly lower risk of developing hypertension (HR 0.46 and 0.44, respectively), as did those with the highest plant-based nitrite intake (HR 0.57). No protective association was observed for animal-derived sources. These findings support promoting plant-based nitrate and nitrite sources as a practical dietary strategy for primary hypertension prevention.

## Abstract (original, from the publication)

In the current study, we have investigated the association between dietary nitrate (NO3)/nitrite (NO2) intakes and the incidence of hypertension (HTN). This study included a total of 1576 men and women (mean age of 36.4 ± 11.7 and 39% men) in the third (2006-2008) phase of the Tehran Lipid and Glucose Study and were followed up until 2018-2022. At the beginning of the study, a semiquantitative food frequency questionnaire was applied to measure dietary intakes of NO3 and NO2. Multivariable-adjusted Cox proportional hazard models for multiple variables were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of incidence of HTN across different quartiles of NO3 and NO2 dietary intakes. Median (interquartile range) daily intake of NO3 and NO2 were 465 (253) mg/d and 9.6 (4.8) mg/d, which were mostly derived from plant-based sources (95.4% and 55.8%, respectively). Participants in the highest quartile of total and plant-based NO₃ intake were associated with a significantly lower risk of HTN (HRQ4 vs. Q1= 0.46; 95% CI, 0.23-0.91; HRQ4 vs. Q1=0.44; 95% CI, 0.22-0.87, in total and plant-based sources, respectively). No significant association was found between animal-based NO₃ intake and HTN incidence. The highest quartile of plant-based NO₂ intake, compared to the lowest, was associated with a lower risk of HTN (HRQ4 vs. Q1 = 0.57; 95% CI, 0.31-0.99) and there was no significant association between animal-based NO₂ intake and the risk of HTN. Higher intakes of total and plant-based NO3 and NO2, compared with lower intakes, were significantly associated with a lower risk of HTN.

Auteurs: Milad Davarpanah, Zahra Bahadoran, Maryam Javadi, Parvin Mirmiran, Fereidoun Azizi

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Bron: Nutrition research (New York, N.Y.), https://doi.org/10.1016/j.nutres.2026.07.010. Bijgewerkt 2026-09-24T00:59:59Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.