{"id":"96b2f1ea737c","type":"article","url":"https://hartvaat.nl/2026/10/01/rusteloze-benen-en-slaapbewegingen-bepalen-lipidenprofiel-bij-slaapapneu/","title":"Rusteloze benen en slaapbewegingen bepalen lipidenprofiel bij slaapapneu","title_en":"Restless legs syndrome determines whether periodic limb movements are associated with altered lipid profiles in sleep-disordered breathing.","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Sleep medicine","doi":"10.1016/j.sleep.2026.109109","source_url":"https://doi.org/10.1016/j.sleep.2026.109109","authors":["Alen Juginovic","Laura Rodman"],"significance":4,"published":"2026-07-27","source_date":"2026-10-01","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/lpa-meten-wanneer-waarom/","https://hartvaat.nl/kennis/lipiden/dyslipidemie-overzicht/"],"congress":"","summary_en":"A cross-sectional analysis of 643 adults with sleep-disordered breathing evaluated whether periodic limb movements (PLM) independently associate with lipid profiles, and whether restless legs syndrome (RLS) modifies this relationship. While PLM alone showed no significant association with cardiometabolic markers, RLS status fundamentally altered the pattern: in RLS-positive patients, higher PLM frequency correlated with elevated HDL, LDL, and total cholesterol, whereas an inverse trend appeared in RLS-negative individuals. These findings suggest that the co-occurrence of RLS and PLM identifies a distinct cardiometabolic phenotype that may benefit from targeted lipid screening in clinical practice.","created":"2026-07-20T00:50:51Z","updated":"2026-08-10T10:38:24Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een cross-sectionele analyse van 643 volwassenen met slaapgestoorde ademhaling onderzochten onderzoekers of periodieke ledemaatbewegingen (PLM) onafhankelijk geassocieerd zijn met lipidenwaarden, en of het syndroom van de rusteloze benen (RLS) deze relatie beïnvloedt. Na correctie voor confounders was PLM alleen niet significant, maar bij patiënten met RLS leidde een hoger PLM-index juist tot verhoogde HDL-, LDL- en totale cholesterolwaarden, terwijl bij RLS-vrije patiënten een omgekeerd verband werd gezien. Deze bevinding suggereert dat de combinatie van RLS en PLM een specifiek cardiometabool fenotype markeert waarvoor gerichte lipidenmonitoring in de klinische praktijk overwogen kan worden.","abstract_original":"OBJECTIVE: Periodic limb movements (PLM) during sleep are common in sleep-disordered breathing (SDB), but their independent association with cardiometabolic markers remains unclear. Restless legs syndrome (RLS), which frequently co-occurs with PLM, may modify this relationship. We investigated whether PLM are independently associated with cardiometabolic risk in SDB, and whether RLS modifies these associations. METHODS: Cross-sectional analysis of 643 adults (mean age 45.9 years, 59.4% male) from the NSRR APOE dataset with in-laboratory polysomnography, PLM index, RLS assessment, and fasting cardiometabolic profiling. Multivariable regression adjusted for age, sex, BMI, and oxygen desaturation index tested associations between log-transformed PLM and each outcome. We then tested whether the association of PLM with lipid levels differed by RLS status by adding interaction terms to the models. Benjamini-Hochberg false discovery rate (FDR) correction was applied. RESULTS: PLM alone were not significantly associated with any cardiometabolic outcome after FDR correction (all FDR p ≥ 0.17). However, RLS status substantially modified the PLM-lipid relationship: this was significant for HDL (β = 4.33, FDR p < 0.001), LDL (β = 8.17, FDR p = 0.008), and total cholesterol (β = 12.29, FDR p < 0.001). In participants with RLS, higher PLM was linked to higher lipids. In those without RLS, higher PLM was linked to lower lipids. This direction reversal indicates that the metabolic significance of PLM depends on concomitant RLS status. CONCLUSIONS: PLM alone do not predict cardiometabolic risk in SDB. However, RLS profoundly modifies the PLM-lipid relationship. The combination of PLM and RLS identifies a distinct cardiometabolic phenotype that may warrant targeted lipid monitoring."}