# D-dimeerwaarde boven 7,6 mg/L duidt op hoger sterfterisico bij hartfalenpatiënten

*geplaatst 2026-10-13 · Hartfalen · Laboratory medicine · doi 10.1093/labmed/lmag072 · https://hartvaat.nl/2026/10/05/d-dimeerwaarde-boven-7-6-mg-l-duidt-op-hoger-sterfterisico-bij-hartfalenpatiente/*

Een cohortstudie van 1575 hartfalenpatiënten toont aan dat een D-dimeerconcentratie boven de 7,6 mg/L samenhangt met een verhoogd risico op overlijden binnen zes maanden. Bij waarden onder deze drempel neemt het sterfterisico met 20% toe per mg/L, terwijl een licht verhoogd D-dimeer juist geassocieerd wordt met een lager heropnamerisico. De bevindingen ondersteunen het gebruik van D-dimeer als aanvullende marker voor risicostratificatie en prognosebeoordeling bij hartfalen.

## English: The relationship between D-dimer and the risk for adverse outcomes in patients with heart failure.

In a cohort of 1,575 hospitalized heart failure patients, D-dimer levels above 7.6 mg/L were independently associated with higher six-month all-cause mortality. For every 1 mg/L increase below this threshold, mortality risk rose by 20%, whereas slightly elevated levels correlated with a modestly lower readmission rate. These findings support incorporating D-dimer into routine risk stratification to identify heart failure patients at higher short-term mortality risk.

## Abstract (original, from the publication)

INTRODUCTION: Insufficient evidence exists for the association between serum dimerized plasmin fragment D (D-dimer), a biomarker for screening thromboembolic diseases, and adverse outcomes in patients with heart failure (HF).We investigated the association between serum D-dimer and the risk of readmission and all-cause mortality in patients with HF. METHODS: We enrolled 1575 patients hospitalized with HF in China between 2016 and 2019. We explored the smooth curve of the nonlinear relationship between serum D-dimer and adverse outcomes. Logistic regression and saturation threshold analyses were also conducted. RESULTS: Smooth curve analysis revealed an inverted U-shaped association between serum D-dimer concentrations and 6-month all-cause mortality. The turning point for serum D-dimer concentration in patients with HF in the highest 6-month mortality risk group was 7.6 mg/L. Among patients with a D-dimer concentration below 7.6 mg/L, each 1-mg/L increase in D-dimer concentration independently contributed to a 20% higher risk for all-cause mortality, independent of other clinical covariates. Regarding readmission risk, smooth curve analysis supported an obvious relationship between serum D-dimer and 6-month readmission risk. Surprisingly, each 1-mg/L increase in D-dimer concentration was independently associated with a 4% lower risk for readmission within 6 months. DISCUSSION: Elevated serum D-dimer concentrations have a strong association with increased risk for 6-month mortality, providing evidence for early risk stratification in HF prognosis.

Auteurs: Xiaoxi He, Ruiping Zheng, Ruigui Zheng

---
Bron: Laboratory medicine, https://doi.org/10.1093/labmed/lmag072. Bijgewerkt 2026-10-06T01:12:36Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.