{"id":"4d99180c9c17","type":"article","url":"https://hartvaat.nl/2026/10/31/proteomisch-panel-en-multimarkertests-onderscheiden-mash-beter-dan-enkelvoudige-/","title":"Proteomisch panel en multimarkertests onderscheiden MASH beter dan enkelvoudige biomarkers — LITMUS","title_en":"Non-invasive tests in metabolic dysfunction-associated steatotic liver disease: the LITMUS prospective multicentre diagnostic accuracy study","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"The Lancet","doi":"10.1016/S0140-6736(26)01145-1","source_url":"https://doi.org/10.1016/S0140-6736(26)01145-1","authors":["Yasaman Vali","Kristy Wonders","Jenny Lee","Guruprasad P Aithal","Rocio Aller","Michael E D Allison","Johanna Arola","Jesus M Banales","Vanesa Bernal-Monterde","Annalisa Berzigotti","Jérôme Boursier","Clifford A Brass","Elisabetta Bugianesi","Jose Luis Calleja","Jeremy F Cobbold","Helena Cortez-Pinto","Javier Crespo","Susan Davies","Ann Driessen","Kevin L Duffin","Mattias Ekstedt","Daniel Forton","Céline Fournier-Poizat","Sven Francque","Andreas Geier","Joseph Gogain","Annette S H Gouw","Hannes Hagström","Adriaan G Holleboom","Prodromos Hytiroglou","Morten Karsdal","Carolin Lackner","Diana J Leeming","Luca Miele","George Papatheodoridis","Valerie Paradis","Michael Pavlides","Juan M Pericàs","Salvatore Petta","Vlad Ratziu","Manuel Romero-Gomez","Jörn M Schattenberg","Detlef Schuppan","Rambabu Surabattula","Ana Paula Silva","Mette Skalshøi Kjær","Beate K Straub","Gianluca Svegliati-Baroni","Dina Tiniakos","Maria Manuela Tonini","Richard Torstenson","Luca V C Valenti","Joanne Verheij","Jeremy Magnanensi","Rebeca Mayo","David Wenn","Hannele Yki-Järvinen","Carla Yunis","Patrick M Bossuyt","Quentin M Anstee","LITMUS Investigators"],"significance":8,"published":"2026-11-06","source_date":"2026-10-31","image":"","kennis":["https://hartvaat.nl/kennis/diagnostiek/cardiale-biomarkers-overzicht/","https://hartvaat.nl/kennis/diagnostiek/galectine-3-st2-hartfalen/"],"congress":"","summary_en":"The prospective multicentre LITMUS study evaluated the diagnostic accuracy of non-invasive tests for metabolic dysfunction-associated steatotic liver disease (MASLD) and MASH. While single markers showed limited performance compared to histology, multimarker panels—particularly a proteomic panel—demonstrated strong diagnostic accuracy. These findings support the integration of non-invasive testing into routine clinical pathways and may inform future guidelines and trial design.","created":"2026-10-30T02:35:47Z","updated":"2026-10-30T02:35:47Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De prospectieve multicenterstudie LITMUS evalueerde de diagnostische nauwkeurigheid van niet-invasieve tests voor metabole dysfunctie-geassocieerde steatotische leverziekte (MASLD) en MASH. Waar enkelvoudige biomarkers matig presteerden ten opzichte van histologie, toonden multimarkerpanels, met name een proteomisch panel, een sterke diagnostische performance. Deze resultaten ondersteunen de invoering van niet-invasieve screeningstrategieën in de klinische praktijk en kunnen toekomstige richtlijnen en trialontwerpen sturen.","abstract_original":"Although single markers resulted in variable and limited performance when compared to histology for detecting at-risk MASH, multimarker panels showed great potential, with a proteomic panel showing strong diagnostic performance. These findings could support the selection and implementation of non-invasive testing strategies in MASLD and inform future clinical guidelines, regulatory evaluation, and clinical trial design."}