{"id":"d0d0a11d3075","type":"article","url":"https://hartvaat.nl/2026/11/01/isometrische-handgreeptraining-verlaagt-dagbloeddruk-bij-hypertensie-rct/","title":"Isometrische handgreeptraining verlaagt dagbloeddruk bij hypertensie — RCT","title_en":"Four weeks of isometric handgrip training results in lower awake ambulatory blood pressure compared with control: a randomized clinical trial.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts"],"tags":[],"journal":"Clinical physiology and functional imaging","doi":"10.1111/cpf.70102","source_url":"https://doi.org/10.1111/cpf.70102","authors":["Patrícia C Oliveira","Gustavo Waclawovsky","Alexandre M Lehnen"],"significance":4,"published":"2026-11-07","source_date":"2026-11-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/bloeddrukmeting-thuismeting-abpm/","https://hartvaat.nl/kennis/hypertensie/ace-remmers-hypertensie/"],"congress":"","summary_en":"In a randomized trial of 67 adults with controlled hypertension, four weeks of supervised isometric handgrip training significantly reduced awake systolic and diastolic blood pressure compared with control (121.8 vs 124.2 mmHg and 76.3 vs 80.8 mmHg, respectively). Lower-limb isometric exercise and 24-hour or sleep blood pressure were unaffected. The findings suggest that brief, targeted isometric training can offer a modest adjunctive benefit for daytime blood pressure control, supporting its inclusion in lifestyle-based hypertension management.","created":"2026-11-01T02:21:21Z","updated":"2026-11-01T02:21:21Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een gerandomiseerde studie bij 67 volwassenen met onder controle staande hypertensie bleek vier weken isometrische handgreeptraining (12 sessies) de dagbloeddruk significant te verlagen ten opzichte van een controlegroep (systolisch 121,8 vs 124,2 mmHg; diastolisch 76,3 vs 80,8 mmHg). Training van grote spiergroepen (knie-extensie) leverde geen vergelijkbaar effect op, noch voor de 24-uurs- noch voor de nachtbloeddruk. Hoewel de bloeddrukdaling bescheiden is, ondersteunt dit onderzoek de toevoeging van korte, intensieve isometrische oefeningen aan het niet-farmacologische behandeladvies bij hypertensie.","abstract_original":"We compared the effects of upper-limb (handgrip) and lower-limb (knee extension) isometric training on ambulatory blood pressure in individuals with controlled hypertension. In this randomized controlled trial, 67 adults receiving antihypertensive medication were allocated to a control group (CG, n = 22), small muscle mass isometric training (SMM, handgrip; n = 22), or large muscle mass isometric training (LMM, knee extension; n = 23). Participants completed 12 supervised sessions over 4 weeks, with the exercise protocols performed at 30% of upper-limb MVC or lower-limb maximal isometric load, respectively. Ambulatory blood pressure outcomes were compared using analysis of covariance (ANCOVA), adjusting for the corresponding baseline office blood pressure. Hourly 24-h profiles were analyzed using generalized estimating equations with Bonferroni-adjusted post hoc tests. Significant between-group differences were observed only for awake ambulatory blood pressure. Compared with CG, SMM showed lower awake systolic blood pressure (121.8 ± 3.1 vs. 124.2 ± 2.6 mmHg; p = 0.017) and awake diastolic blood pressure (76.3 ± 3.6 vs. 80.8 ± 4.2 mmHg; p = 0.009). No significant differences were observed between LMM and CG, between the two exercise groups, or for 24-h and sleep blood pressure. These findings indicate that, after 4 weeks of supervised isometric training, modest between-group differences in awake ambulatory blood pressure were observed only for handgrip training compared with the control group. Greater muscle mass recruitment did not result in superior antihypertensive effects, suggesting that the chronic blood pressure response to isometric exercise is not determined solely by the amount of muscle mass involved. Trial registration: \"ClinicalTrials.gov,\" \"NCT07147595.\""}