{"id":"9b425e3c311a","type":"article","url":"https://hartvaat.nl/2026/11/04/hoge-remantecholesterol-inflammatoire-index-correleert-met-cardiometabole-multim/","title":"Hoge remantecholesterol-inflammatoire index correleert met cardiometabole multimorbiditeit — CHARLS","title_en":"Remnant Cholesterol Inflammatory Index and its Association With Cardiometabolic Multimorbidity in Middle-Aged and Advanced-Aged Individuals: Evidence From the China Health and Retirement Longitudinal Study.","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Medical science monitor : international medical journal of experimental and clinical research","doi":"10.12659/MSM.953230","source_url":"https://doi.org/10.12659/MSM.953230","authors":["Yuya Wang","Qihui Dong","Wei Wang","Simin Tang","Na Yu","Yuqi Wang","Chong Zou"],"significance":3,"published":"2026-11-11","source_date":"2026-11-04","image":"https://hartvaat.nl/global/img/0595aa5e1e3c.webp","kennis":["https://hartvaat.nl/kennis/preventie/risicofactoren-cardiovasculair/","https://hartvaat.nl/kennis/lipiden/dyslipidemie-overzicht/"],"congress":"","summary_en":"A longitudinal cohort study of 6,173 middle-aged and older Chinese adults found that a higher remnant cholesterol inflammatory index (RCII) is associated with an increased risk of cardiometabolic multimorbidity (coexistence of at least two of hypertension, diabetes, heart disease, or stroke). In fully adjusted models, each unit increase in ln(RCII) corresponded to a relative risk of 1.13 (95% CI: 1.09–1.16), with the highest quartile showing a 1.69-fold higher risk compared to the lowest quartile. However, the index demonstrated only modest discriminatory power (AUC 0.607), indicating it currently lacks sufficient predictive accuracy to be integrated into routine cardiovascular risk assessment.","created":"2026-11-05T02:08:26Z","updated":"2026-11-05T02:08:28Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een cohortstudie onder 6173 Chinese volwassenen van middelbare en gevorderde leeftijd toont aan dat een hogere remantecholesterol-inflammatoire index (RCII) samenhangt met een verhoogd risico op cardiometabole multimorbiditeit (minstens twee van hypertensie, diabetes, hart- of vaatziekte). In het volledig aangepaste model was elk eenheidstoename in de gelogaritmiseerde RCII-uitslag geassocieerd met een relatief risico van 1,13 (95% BI: 1,09–1,16), terwijl deelnemers in het hoogste kwartiel een risico van 1,69 hadden ten opzichte van het laagste kwartiel. De voorspellende waarde van de index is echter beperkt (AUC 0,607), wat betekent dat de index op dit moment geen directe toevoeging is aan de klinische risicoscreening.","abstract_original":"BACKGROUND The association between remnant cholesterol inflammatory index (RCII) and cardiometabolic multimorbidity (CMM) remains unclear. RCII is defined as: {Total Cholesterol - (High-Density Lipoprotein Cholesterol + Low-Density Lipoprotein Cholesterol)] × High-Sensitivity C-Reactive Protein/10}. This study examined the association between baseline RCII and CMM among middle-aged and older adults in China. MATERIAL AND METHODS This study analyzed data from the China Health and Retirement Longitudinal Study (CHARLS), including 6173 participants. CMM was defined as the coexistence of at least 2 of 4 conditions: hypertension, diabetes, heart disease, or stroke. Participants were grouped according to the quartiles of natural log-transformed RCII (lnRCII) values. Modified Poisson regression models, restricted cubic splines, and receiver operating characteristic curves were used to examine the relationship between lnRCII and CMM outcomes. RESULTS In the cohort, 1832 cases of CMM occurred, and the incidence of CMM was highest in the lnRCII highest-quartile group (P<0.001). In the fully adjusted model, each unit of increase in lnRCII was associated with a higher risk of CMM (RR=1.13, 95% CI: 1.09-1.16), and participants in the highest quartile had a higher risk than those in the lowest quartile (RR=1.69, 95% CI: 1.50-1.90). The area under the curve for lnRCII was 0.607 (95% CI: 0.592-0.622), indicating modest discriminatory ability. CONCLUSIONS Higher baseline lnRCII was associated with an increased risk of incident CMM in middle-aged and older Chinese adults. Although RCII may capture combined information on remnant cholesterol and inflammation, its clinical predictive value requires further validation."}