# Vitamine K-biomarkers tonen na correctie voor triglyceriden omgekeerd verband met buikvet en diabetes

*geplaatst 2026-11-13 · Cholesterol · European journal of nutrition · doi 10.1007/s00394-026-04146-w · https://hartvaat.nl/2026/11/06/vitamine-k-biomarkers-tonen-na-correctie-voor-triglyceriden-omgekeerd-verband-me/*

In een cross-sectionele analyse van de Inter99-cohortstudie (n=2.195, gemiddelde leeftijd 68 jaar) onderzochten onderzoekers de associaties tussen circulerende vitamine K-biomarkers en cardiometabole risicofactoren. Na correctie voor triglyceriden bleken hogere PK- en MK-niveaus omgekeerd geassocieerd met centraal vet (OR 0,86 en 0,61) en diabetes (OR 0,81 en 0,33), terwijl dp-ucMGP onafhankelijk van triglyceriden samenhangde met meer adipositeit. Deze bevindingen benadrukken dat triglyceriden een cruciale confounder zijn bij het interpreteren van vitamine K-status en onderstrepen de link tussen verminderde MGP-carboxylering en metabole verstoringen.

## English: Associations between biomarkers of vitamin K and cardiovascular disease risk factors: the role of lipids.

In a cross-sectional analysis of the Inter99 cohort (n=2,195, mean age 68), researchers examined associations between circulating vitamin K biomarkers and cardiometabolic risk factors. After adjusting for triglycerides, higher phylloquinone and total menaquinone levels were inversely associated with central obesity (OR 0.86 and 0.61) and diabetes (OR 0.81 and 0.33), whereas elevated dp-ucMGP remained linked to greater adiposity independent of triglycerides. These findings highlight triglycerides as a key confounder in vitamin K research and reinforce the association between impaired matrix Gla protein carboxylation and metabolic dysfunction.

## Abstract (original, from the publication)

PURPOSE: Emerging evidence indicates that vitamin K is important not only for its role in blood coagulation activation, but also for cardiovascular health. However, the results are equivocal, and due to the lipophilic nature of vitamin K, adjustment for triglycerides may be important. We investigated the associations between levels of circulating vitamin K vitamers, phylloquinone (PK) and total menaquinones (MK), and dephospho-undercarboxylated matrix Gla protein (dp-ucMGP, a biomarker of functional vitamin K status), with multiple cardiovascular disease risk factors and adjusted for triglycerides. METHODS: From the population-based Inter99 cohort, 2,195 participants had available fasting blood samples from which dp-ucMGP, PK, and MK-4 to MK-10 were analysed (mean age, ± SD: 68, ± 7 years, 48% female). Cross-sectional associations with cardiovascular disease risk factors were examined per doubling of vitamin K biomarkers using multivariable regression models. RESULTS: Both PK and total MK were positively associated with hypertriglyceridemia: OR (95%CI) 1.91, (1.69, 2.18) and 13.1, (7.55, 23.4), respectively, but not measures of adiposity and diabetes. However, after triglyceride adjustment, higher PK and total MK were inversely associated with central obesity: 0.86, (0.79, 0.95) and 0.61, (0.37, 0.98), respectively, and diabetes: 0.81, (0.69, 0.95) and 0.33, (0.13, 0.81), respectively. Higher dp-ucMGP was associated with hypertriglyceridemia: 1.50, (1.08, 2.09). After adjustment for triglycerides, higher dp-ucMGP remained associated with central obesity: 2.81, (2.16, 3.70) and obesity: 3.31, (2.50, 4.42). CONCLUSION: After accounting for triglycerides, both PK and total MK were inversely associated with measures of adiposity and diabetes, suggesting that blood triglyceride levels need to be accounted for when considering circulating vitamin K levels. Higher dp-ucMGP, reflecting reduced vitamin K-dependent MGP carboxylation, was associated with adiposity markers independent of triglycerides.

Auteurs: Vasileios Michalopoulos, Nicola P Bondonno, Pratik Pokharel, Julie Aaberg Lauridsen, Jette Jakobsen, Sarah L Booth, Camilla Friis Bryde Nielsen, Line Lund Kårhus, Line Tang Møllehave, Niklas Rye Jørgensen, Kirsten Schroll Bjørnsbo, Charlotte Brøns, Torben Hansen, Allan Vaag, Allan Linneberg, Anne Ahrendt Bjerregaard

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Bron: European journal of nutrition, https://doi.org/10.1007/s00394-026-04146-w. Bijgewerkt 2026-11-07T01:57:36Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.