{"id":"bdc8f502f982","type":"article","url":"https://hartvaat.nl/2026/12/01/aerobe-training-induceert-post-exercitiehypotensie-bij-hypertensiepatienten-cros/","title":"Aerobe training induceert post-exercitiehypotensie bij hypertensiepatiënten — crossoverstudie","title_en":"Characteristics of post-exercise responders versus non-responders following aerobic or isometric exercise in physically inactive adults of African and South Asian descent with high-normal blood pressure or grade I hypertension.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Blood pressure","doi":"10.1080/08037051.2026.2717787","source_url":"https://doi.org/10.1080/08037051.2026.2717787","authors":["Marina Bersaoui","Se-Sergio Baldew","Kwame van der Hilst","Jerry Toelsie","Veronique Cornelissen"],"significance":4,"published":"2026-09-10","source_date":"2026-12-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/hypertensie-en-ckd/","https://hartvaat.nl/kennis/hypertensie/classificatie-bloeddruk-esc-2024/"],"congress":"","summary_en":"A crossover trial of 47 physically inactive adults with high-normal blood pressure or grade 1 hypertension found that 46% achieved a clinically meaningful post-exercise hypotensive response (≥5 mmHg reduction) following 30 minutes of aerobic exercise, compared with 28% after isometric handgrip training. Aerobic responders exhibited greater reductions in aortic augmentation index and more favourable increases in stroke volume and cardiac output, indicating that the blood pressure-lowering effect is largely driven by specific haemodynamic adaptations. The substantial interindividual variability in exercise-induced blood pressure responses underscores the need for personalised physical activity prescriptions in hypertension management.","created":"2026-09-04T00:48:13Z","updated":"2026-09-04T00:48:13Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een crossoverstudie onder 47 fysiek inactieve volwassenen met een hoge normale bloeddruk of graad I hypertensie toonde aan dat 46% een significante bloeddrukdaling (≥5 mmHg) vertoonde na 30 minuten aerobe training, tegenover 28% na isometrische handgreeptraining. Responders op aerobe training hadden een grotere afname in de aortale augmentatie-index en een gunstigere toename van het hartminuutvolume, wat suggereert dat de post-exercitiehypotensie voornamelijk wordt gedreven door fysiologische adaptaties. Deze resultaten benadrukken de grote interindividuele variabiliteit in de bloeddrukreactie op beweging en ondersteunen het belang van gepersonaliseerde leefstijlinterventies bij de behandeling van hypertensie.","abstract_original":"OBJECTIVE: To investigate interindividual variability in post-exercise hypotension (PEH) and to characterise cardiovascular and autonomic differences between responders and non-responders following aerobic and isometric exercise in adults of African and South Asian descent with elevated blood pressure (BP). METHODS: Physically inactive adults of African and South Asian descent living in Suriname (18-65 years) with high-normal BP or grade I hypertension participated in a randomised controlled crossover trial. In this randomised cross-over trial, 47 adults (50.1 ± 10.8 years; 38% male) with high-normal blood pressure or grade I hypertension completed three conditions: aerobic exercise (30 min at 40-60% heart rate reserve), isometric handgrip exercise, and a non-exercise control. Ambulatory BP was assessed over 24 h. PEH was defined as the net effect: (post-exercise - pre-exercise) - (post-control - pre-control). Participants were classified as responders if daytime BP decreased ≥5 mmHg. Arterial stiffness, cardiac, and autonomic parameters were assessed. RESULTS: Following aerobic exercise, 46% of participants were classified as systolic responders compared with 28% after isometric exercise. No baseline differences were observed in demographic or clinical characteristics between responders and non-responders, suggesting that PEH variability may reflect underlying physiological rather than clinical differences. Aerobic responders demonstrated greater reductions in aortic augmentation index (-19.4% vs. -10.9%, p = 0.05), larger increases in stroke volume (+8.1 vs. -5.3 mL, p = 0.05) and cardiac output (+1.54 ± 1.89 vs. +0.58 ± 1.60 L/min, p = 0.009), and more favourable autonomic recovery. Among all variables, only the change in cardiac output was associated with PEH magnitude (r = -0.46, p = 0.006). No consistent physiological differences were observed following isometric exercise. CONCLUSION: PEH following aerobic exercise is characterised by a distinct responder phenotype associated with greater reductions in aortic augmentation index and favourable cardiac adaptations. These findings highlight substantial interindividual variability in BP responses and support the need for individualised exercise strategies in hypertension management."}