# Bi-atriale reservoirstrain onderscheidt cardiale amyloïdose van hypertrofie — CMR-studie

*geplaatst 2026-11-10 · Hartfalen · International journal of cardiology. Heart & vasculature · doi 10.1016/j.ijcha.2026.102032 · https://hartvaat.nl/2026/12/01/bi-atriale-reservoirstrain-onderscheidt-cardiale-amyloidose-van-hypertrofie-cmr-/*

Een kleine CMR-studie vergeleek de atriale reservoirstrain bij patiënten met cardiale amyloïdose (CA) en hypertrofie (HCM). De rechteratriumstrain was significant lager bij CA (10,8% vs 22,1%; p=0,005), en bleef significant na correctie voor meervoudige toetsing. Hoewel de studie beperkt is door de kleine steekproef, suggereert het resultaat dat atriale reservoirstrain een nuttige, contrastvrije aanvulling kan zijn bij het differentiëren van CA van HCM in de cardiologische praktijk.

## English: Reduced bi-atrial reservoir strain in patients with cardiac amyloidosis: a cardiac magnetic resonance feature-tracking study.

A small CMR study compared atrial reservoir strain in patients with cardiac amyloidosis (CA) versus hypertrophic cardiomyopathy (HCM). Right atrial strain was significantly lower in CA (10.8% vs 22.1%; p=0.005) and remained significant after Bonferroni correction. While limited by a small sample size, the findings suggest that atrial reservoir strain may serve as a useful, contrast-free adjunct to differentiate CA from HCM in clinical practice.

## Abstract (original, from the publication)

BACKGROUND: Although heart strain analysis is useful for diagnosing cardiac amyloidosis (CA), it remains unclear which chamber best distinguishes CA from hypertrophic cardiomyopathy (HCM). This study analyzed strain in all four cardiac chambers in patients with CA and HCM using cardiac magnetic resonance (CMR) feature-tracking. METHODS: We enrolled 30 patients with left ventricular hypertrophy (15 with CA and 15 with HCM) and 17 healthy volunteers as a reference. Participants underwent 1.5-Tesla CMR to assess volume, function, and strain parameters in both ventricles and atria. The primary analysis comprised four comparisons between CA and HCM, one representative parameter per chamber (bi-ventricular longitudinal strain and bi-atrial reservoir strain), with Bonferroni correction (P < 0.0125). Additionally, exploratory analyses of the other parameters were conducted comparing patients with CA to HCM. RESULTS: Left atrial (LA) and right atrial (RA) reservoir strain were lower in CA than in HCM (LA: 7.1 ± 4.1% vs. 10.3 ± 3.9%, P = 0.035; RA: 10.8 ± 6.9% vs. 22.1 ± 12.9%, P = 0.005), whereas ventricular longitudinal strain did not differ. After Bonferroni correction, only RA reservoir strain remained significant. In an exploratory receiver operating characteristic analysis, the areas under the curve for LA and RA reservoir strain were 0.73 and 0.78, respectively, and did not differ significantly. CONCLUSION: Bi-atrial reservoir strain was lower in CA than in HCM, and the difference in RA reservoir strain remained significant after accounting for multiplicity. Atrial reservoir strain may provide adjunctive, contrast-free functional information to help differentiate CA from HCM.

Auteurs: Ryosuke Kato, Hidehiro Iwakawa, Hirokazu Yoshida, Yohei Sasaki, Chihiro Miura, Nobuhiro Suzuki, Ryota Kaimori, Hiroyuki Watanabe

---
Bron: International journal of cardiology. Heart & vasculature, https://doi.org/10.1016/j.ijcha.2026.102032. Bijgewerkt 2026-11-03T02:15:24Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.