{"id":"fa7a75a687a6","type":"article","url":"https://hartvaat.nl/2026/12/01/higs-score-voorspelt-pacemaker-implantatie-en-sterfte-na-tavi/","title":"HIGS-score voorspelt pacemaker-implantatie en sterfte na TAVI","title_en":"Association of the HIGS score with permanent pacemaker implantation and mortality after transcatheter aortic valve implantation.","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":[],"journal":"Annals of medicine","doi":"10.1080/07853890.2026.2715272","source_url":"https://doi.org/10.1080/07853890.2026.2715272","authors":["Özkan Karaca","Burak Toprak","Nihat Söylemez","Mustafa Ekici","Abdulkadir Bilgiç","Ahmet Turhan Kılıç","Samet Yımaz","Ali Orçun Sürmeli","Sonay Oğuz","Mehmet Ballı","Rıdvan Bora","Serdar Keçeoğlu"],"significance":5,"published":"2026-08-19","source_date":"2026-12-01","image":"","kennis":["https://hartvaat.nl/kennis/kleplijden/tavi-transcatheter-aortaklepimplantatie/","https://hartvaat.nl/kennis/kleplijden/esc-richtlijn-kleplijden-2021/"],"congress":"","summary_en":"In a retrospective single-center study of 196 TAVI patients, the Hematological Inflammatory Global Score (HIGS) derived from routine blood parameters was independently associated with permanent pacemaker implantation (PPI) and in-hospital mortality. Higher HIGS values correlated with a significantly increased risk of PPI (OR 3.96) and death (OR 4.92), while also improving the predictive performance of conventional clinical models. Although HIGS shows promise as a readily available risk-stratification tool, prospective multicenter validation is needed before routine clinical adoption.","created":"2026-08-13T00:52:09Z","updated":"2026-08-13T00:52:09Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een retrospectieve single-center studie (n=196) bleek de Hematological Inflammatory Global Score (HIGS), berekend uit routinematige bloedwaarden, onafhankelijk geassocieerd met permanente pacemaker-implantatie (PPI) en ziekenhuismortaliteit na TAVI. Patiënten met een hogere HIGS hadden een significant verhoogd risico op PPI (OR 3,96) en overlijden (OR 4,92), en de score verbeterde de discriminatie van bestaande klinische modellen. Hoewel de HIGS een eenvoudige en direct beschikbare risicostratificatietool lijkt, is prospectief multicenter onderzoek nodig om de klinische toepasbaarheid te bevestigen.","abstract_original":"BACKGROUND: Permanent pacemaker implantation (PPI) and early mortality remain important complications after transcatheter aortic valve implantation (TAVI). The Hematological Inflammatory Global Score (HIGS), derived from routine hematological parameters, may provide prognostic information after TAVI. This study evaluated the association of HIGS with PPI and in-hospital mortality. METHODS: This retrospective single-center study included 196 consecutive patients undergoing TAVI (mean age 78.2 ± 6.9 years; 71.4% male). HIGS was calculated using standardized values of red cell distribution width, platelet distribution width, and immature granulocyte percentage. Associations with outcomes were assessed using logistic regression, and discrimination was evaluated by receiver operating characteristic analysis. RESULTS: PPI occurred in 43 patients (21.9%) and in-hospital mortality in 34 (17.3%). HIGS was higher in patients with PPI and in those who died (both p < 0.001). In multivariable analysis, HIGS remained independently associated with PPI (OR 3.96, 95% CI 1.79-8.76, p < 0.001) and mortality (OR 4.92, 95% CI 2.12-11.41, p < 0.001). HIGS showed good discrimination for PPI (AUC 0.84) and mortality (AUC 0.87), and improved conventional clinical models. CONCLUSIONS: Higher HIGS values were independently associated with PPI and in-hospital mortality after TAVI. HIGS may be a simple, readily available risk-stratification marker, although prospective multicenter validation is required."}