# J-vormige relatie tussen stresshyperglykemië-verhouding en sterfte bij hypertensie — MIMIC-IV

*geplaatst 2026-08-31 · Hypertensie · Blood pressure · doi 10.1080/08037051.2026.2709810 · https://hartvaat.nl/2026/12/01/j-vormige-relatie-tussen-stresshyperglykemie-verhouding-en-sterfte-bij-hypertens/*

In een retrospectieve cohortstudie van 2088 hypertensiepatiënten op de ICU onderzochten onderzoekers de prognostische waarde van de stresshyperglykemië-verhouding (SHR) voor in-hospital- en 1-jaarssterfte. Een hogere SHR was geassocieerd met een verhoogd sterftecijfer (HR 1,93 voor in-hospital en HR 1,66 voor 1-jaarssterfte), waarbij een J-vormig verband werd aangetoond en de hoogste SHR-categorie het grootste risico vertoonde (HR 3,29 en HR 1,74). Deze bevindingen suggereren dat de SHR een bruikbaar complementair risicoselectie-instrument kan zijn voor kritische hypertensiepatiënten, hoewel prospectieve validatie nodig is voordat het routinematig in de klinische praktijk wordt geïntegreerd.

## English: J‑shaped link of stress hyperglycaemia ratio with in-hospital and 1-year mortality in hypertension patients: based on the MIMIC-IV database.

A retrospective analysis of 2,088 hypertensive ICU patients evaluated the association between the stress hyperglycaemia ratio (SHR) and both in-hospital and 1-year mortality. Higher SHR levels demonstrated a J-shaped relationship with adverse outcomes, with each unit increase linked to significantly elevated risks (HR 1.93 for in-hospital and HR 1.66 for 1-year mortality), while the highest SHR quartile carried the greatest mortality risk (HR 3.29 and HR 1.74, respectively). These findings highlight SHR as a potential adjunctive prognostic marker in critically ill hypertensive patients, though external validation is required before routine clinical adoption.

## Abstract (original, from the publication)

BACKGROUND: Stress hyperglycaemia ratio (SHR) is notably linked with unfavourable prognoses. Nevertheless, this correlation in hypertension is elusive. This paper uncovered a link of SHR with mortality in hypertension populations. METHODS: Hypertension patients in ICUs were enrolled from the MIMIC database. The outcomes assessed encompassed in-hospital and 1-year death. SHR was categorised into four groups, and its connection with mortality was assessed using Cox regression analysis. The restricted cubic spline method was leveraged to appraise the non-linear link of SHR with mortality. RESULTS: 2088 patients were enrolled, with 8.67% of in-hospital and 19.92% of 1-year mortality. As a continuous variable, each one-unit enhancement in SHR was connected with an elevation in in-hospital (HR, 1.93 [95% CI: 1.50-2.47]) and 1-year deaths (HR, 1.66 [95% CI: 1.37-2.01]); SHR as a categorical variable, the Q4 group exhibited enhanced in-hospital (HR, 3.29 [95% CI: 1.89-5.74]) and 1-year death (HR, 1.74 [95% CI: 1.29-2.35]). There was a J-shaped connection of SHR with in-hospital and 1-year deaths. CONCLUSION: SHR index can predict in-hospital and 1-year deaths in individuals with critical hypertension.

Auteurs: Dan Zhao, Fan Wang, Yanzhi Ding, Xinshun Gu

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Bron: Blood pressure, https://doi.org/10.1080/08037051.2026.2709810. Bijgewerkt 2026-08-25T00:48:01Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.