# Weight-adjusted waist index voorspelt cardiovasculaire sterfte bij chronische nierziekte

*geplaatst 2026-09-04 · Nierziekte · Renal failure · doi 10.1080/0886022X.2026.2718572 · https://hartvaat.nl/2026/12/01/weight-adjusted-waist-index-voorspelt-cardiovasculaire-sterfte-bij-chronische-ni/*

In een prospectieve cohortstudie met 5.381 NHANES-deelnemers met chronische nierziekte (CKD) bleek een hogere weight-adjusted waist index (WWI) sterk geassocieerd met een verhoogd risico op cardiovasculaire sterfte (HR 1,73) en alle-oorzaak sterfte (HR 1,45) na een mediane follow-up van 79 maanden. De associatie werd gedeeltelijk gemediëerd door systemische ontsteking, en de WWI toonde een goede voorspellende waarde (AUC 0,793 voor CV-sterfte). Deze antropometrische maat kan helpen bij het stratificeren van het cardio-nyro-metabole risico in de dagelijkse praktijk, naast standaardobesitasindices.

## English: Weight-adjusted waist index and risk of cardiovascular and all-cause mortality in chronic kidney disease: NHANES 2005-2018 analysis of 5,381 adults.

In a prospective cohort analysis of 5,381 US adults with chronic kidney disease (CKD), a higher weight-adjusted waist index (WWI) was significantly associated with increased risks of cardiovascular mortality (HR 1.73) and all-cause mortality (HR 1.45) over a median follow-up of 79 months. Systemic inflammation partially mediated this relationship, and WWI demonstrated strong predictive accuracy (AUC 0.793 for CVD mortality). Incorporating WWI into routine risk stratification may help identify high-risk cardio-renal-metabolic phenotypes beyond conventional obesity measures.

## Abstract (original, from the publication)

Central adiposity is a key driver of cardiovascular risk in chronic kidney disease (CKD), yet conventional obesity indices incompletely capture this risk. The weight-adjusted waist index (WWI) is an emerging anthropometric measure that integrates abdominal adiposity independent of body weight, but its prognostic relevance in CKD remains unclear. This prospective cohort study utilized data from the National Health and Nutrition Examination Survey (NHANES 2005-2018) and the National Death Index. Over a median follow-up of 79 months, higher WWI quartiles were associated with progressively increased risks of CVD (highest vs. lowest quartile OR: 1.81, 95% CI: 1.39-2.34) and mortality (CVD HR: 1.73, 95% CI: 1.15-2.60; all-cause HR: 1.45, 95% CI: 1.22-1.72) among 5,381 participants. Subgroup and sensitivity analyses further confirmed the robustness of these findings. Mediation analysis revealed that both the neutrophil-to-lymphocyte ratio and the systemic inflammation response index significantly mediated the associations between WWI and all-cause mortality, as well as between WWI and CVD-specific mortality. In fully adjusted Model 2, receiver operating characteristic curve analysis showed area under the curve values for WWI in relation to CVD mortality and all-cause mortality of 0.793 and 0.763, respectively. WWI is a robust predictor of cardiovascular and all-cause mortality in U.S. adults with CKD, with systemic inflammation partially mediating this relationship. Incorporating WWI into CKD risk stratification may improve identification of high-risk cardio-kidney-metabolic phenotypes.

Auteurs: Zhendong Wang, Xiumei Li, Xiangrong Zhu, Qiufa Hao, Fanwu Kong, Guangyi Liu

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Bron: Renal failure, https://doi.org/10.1080/0886022X.2026.2718572. Bijgewerkt 2026-08-29T00:49:19Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.