{"id":"a82a321dbca5","type":"article","url":"https://hartvaat.nl/2026/12/31/mechanismen-van-hypertensie-tot-hart-en-hersenvaatziekten-een-uitgebreid-overzic/","title":"Mechanismen van hypertensie tot hart- en hersenvaatziekten: een uitgebreid overzicht","title_en":"Mechanisms linking hypertension to cardiovascular and cerebrovascular diseases and their clinical implications: A comprehensive review.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts","internist"],"tags":["acuut-hartfalen","aprocitentan","bloeddrukbehandeling","cardio-renaal-metabool","cardiorenal-behandelstrategie","diabetes-en-hart","endotheel","endothelineantagonisten","obesitas","ras-remmers","renale-denervatie","resistente-hypertensie","resistente-hypertensie-aldosteronremmers","vrouwen","zwangerschap-hart"],"journal":"Clinical and experimental hypertension (New York, N.Y. : 1993)","doi":"10.1080/10641963.2026.2631606","source_url":"https://doi.org/10.1080/10641963.2026.2631606","authors":["Guangya Li","Jing Jing Zhang","Xiaojie Mou","Xin Zhuo","Weikai Li","Shenghao Zhang","Shuang Qi","Xiubin Li"],"significance":4,"published":"2026-03-01","source_date":"2026-12-31","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/behandeldoelen-bloeddruk/","https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/"],"congress":"","summary_en":"This comprehensive review summarises how hypertension interacts with obesity, metabolic syndrome, sleep apnoea, and pregnancy to drive coronary heart disease and stroke, discussing blood pressure targets and pharmacotherapy across diverse populations.","created":"2026-07-03T10:25:04Z","updated":"2026-07-03T18:38:11Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze review vat de huidige kennis samen over hoe hypertensie — in wisselwerking met obesitas, metabool syndroom, slaapapneu en zwangerschap — leidt tot coronaire hartziekten en beroertes. De auteurs bespreken ook de impact van bloeddrukdoelen en farmacotherapie in diverse patiëntenpopulaties.","abstract_original":"Hypertension, one of the most prevalent chronic conditions worldwide, stands as a principal risk factor for cardiovascular and cerebrovascular diseases, including coronary heart disease and stroke. Recent advances have clarified a graded, dose-response relationship in which higher blood pressure is consistently associated with increased vascular event risk, with relative risks commonly ranging from modest elevations (~1.2) at the lower end of above-optimal blood pressure to substantially higher levels (>3.0) in more severe hypertension categories. This review synthesizes current evidence on how hypertension influences the incidence and progression of cardiovascular and cerebrovascular diseases, emphasizing its interplay with comorbid conditions such as obesity, metabolic syndrome, pregnancy-induced hypertension, and sleep apnea. Additionally, it explores the impact of blood pressure management targets on the prevention of adverse vascular events and evaluates the safety and efficacy of pharmacological treatments in diverse patient populations. Environmental contributors and their role in modulating disease risk are also addressed. By integrating epidemiological data with clinical research findings, this article aims to provide a comprehensive theoretical framework and practical guidance for the prevention and management of cardiovascular and cerebrovascular complications in hypertensive patients."}