Systematische review: welke factoren voorspellen langetermijnrisico op beroerte na TIA of kleine beroerte?

Background: Patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of subsequent stroke that persists for at least 10 years. We aimed to identify prognostic factors associated with long-term risk of stroke in this patient group, and estimate their population attribution fraction (PAF).Methods: A systematic review was performed of MEDLINE, Embase, and Web of Science for cohort studies including patients with TIA or minor stroke that evaluated factors for subsequent stroke over a follow-up period of ≥1 year. We pooled hazard ratios adjusted for relevant confounders using random-effect meta-analysis and determined the PAF of factors based on their pooled prevalence and adjusted hazard ratio (aHR). We assessed certainty of evidence using the Grading of Recommendations, Assessment, Development, and Evaluation approach. The study is registered in PROSPERO (CRD42023476551).Results: From 14 732 identified citations, we included 28 cohort studies comprising 86 81