Dynamische controle van Na-Cl-cotransporter door WNK1-kinase: bifasische respons op kalium

Arterial blood pressure is influenced not only by salt intake but also by potassium (K+) consumption. Low dietary K+ is associated with higher blood pressure, whereas high K+ intake has a blood pressure–lowering effect. This is partly explained by the role of the Na-Cl cotransporter (NCC) in the distal convoluted tubule, which modulates K+ excretion. In the collecting duct, K+ excretion depends on the luminal negative voltage generated by the sodium reabsorption through the epithelial sodium channel ENaC, which, in turn, depends on the amount of sodium delivery due to the upstream activity of NCC.