Hypoxie-responsieve tRNA-fragmenten als regulatoren van RNA-autofagie en nierbescherming

Autophagy/macroautophagy is well known for maintaining cellular homeostasis and is induced in kidney diseases.1,2 The significance of RNA autophagy, which targets defective RNA via the autophagosome-lysosome pathway, is emerging as a distinct form of selective autophagy that involves RNA recycling. Granulophagy recycles nontranslating mRNA-protein complexes in P-bodies and stress granules, whereas ribophagy targets ribosomes and ribosomal RNA complexes.3 Although RNA autophagy-mediated mRNA degradation and the cytoplasmic degradation pathways, such as canonical decay and the surveillance system, are both capable of clearing defective mRNA, the former has several unique features.