Invloed van leeftijd, geslacht en ras op testinterpretatie bij primair aldosteronisme

BACKGROUND:New guidelines recommend testing for primary aldosteronism (PA) in all people with hypertension. Interpreting population-based results for PA will require understanding the influence of demographic characteristics.METHODS:In total, 858 adults from across the US meeting traditional guideline criteria for PA testing underwent testing. The influence of demographic factors on test result interpretations was assessed after multivariable adjustment.RESULTS:Mean age was 62±11 years, with 54.6% women, 14% Black, and 22.9% Hispanic. Independent of antihypertensive medications and clinical comorbidities, participants aged ≥70 years had 24% lower aldosterone (P<0.05), 48% lower renin activity (P<0.001), and trended toward higher aldosterone-to-renin ratio (52% higher;P=0.14), compared with those <50 years. Aldosterone levels were higher in women compared with men across the lifespan. Black participants had 81% higher aldosterone-to-renin ratio than White participan