NOX4 en metabole stress in nieren bij zoutgevoelige hypertensie

Hypertension, Volume 83, Issue 3, Page e25718, March 1, 2026. BACKGROUND:Salt-sensitive (SS) hypertension is associated with oxidative stress and impaired renal metabolism, but the mechanistic link remains unclear. We investigated the role of NOX4 (NADPH oxidase 4)–derived reactive oxygen species in shaping renal metabolic and vascular responses to high-salt intake in SS hypertension.METHODS:Male Dahl SS and SSNOX4−/−rats were maintained on a low-salt (0.4% NaCl) diet and then exposed to high salt (4.0% NaCl) for 21 days. Mean arterial pressure and renal blood flow were continuously measured, with intermittent arterial and renal venous sampling. The glomerular filtration rate was measured in separate groups of rats. Transcriptomic and metabolomic profiling of renal cortex, outer medulla, plasma, and urine was performed.RESULTS:High-salt intake led to progressive hypertension in SS rats, accompanied by transcriptomic and metabolic patterns suggestive of increased glutamate utilization,