Geslachtsspecifieke exosoom-inhoud onthult nieuwe mechanismen van zoutgevoelige hypertensie

Hypertension, Volume 83, Issue 3, Page e25949, March 1, 2026. BACKGROUND:Hypertension is a multifactorial disease influenced by sex hormones, with notable sex-specific differences in its development and progression. Extracellular vesicles have emerged as important mediators in hypertension pathophysiology. This study aimed to investigate sex-specific extracellular vesicle–derived microRNA and protein profiles in deoxycorticosterone acetate-salt–induced hypertension.METHODS:Male and female C57BL/6J mice underwent deoxycorticosterone acetate-salt treatment, with blood pressure monitored via telemetry and cardiac function assessed using echocardiography and invasive hemodynamics. Extracellular vesicles from plasma and cerebrospinal fluid were isolated and analyzed for microRNA (high-throughput RNA sequencing) and protein (liquid chromatography–mass spectrometry) content. To determine the contribution of sex hormones, gonadectomy was performed before deoxycorticosterone acetate-salt exposu