Overgang van AKI naar CKD: rol van niermacrofagen en neutrofielen

Chronic kidney disease (CKD), characterized by irreversible kidney damage and a decline in kidney function for at least 3 months, affects 15% of adults worldwide and is tightly linked to kidney failure, cardiovascular disease, mental disorders, and heightened susceptibility to infections. Acute kidney injury (AKI) occurs in 23% of hospitalized patients, is associated with in-hospital mortality,1 and predisposes patients to CKD.2 After AKI, proximal tubular cells (PTCs) fail to repair through multifaceted mechanisms, including cell cycle arrest at the G2/M phase, maladaptive dedifferentiation (i.e., partial epithelial-mesenchymal transition or epithelial cell plasticity), mitochondrial dysfunction, and epigenetic alteration.