Circulerend MALAT1 bij pre-eclampsie en cardiometabool risico

Hypertension, Volume 83, Issue 3, Page e26379, March 1, 2026. BACKGROUND:Preeclampsia is a hypertensive disorder affecting 2% to 8% of pregnancies. Women with a history of preeclampsia have an increased risk of cardiovascular disease. The long noncoding RNAMALAT1is shown to regulate inflammatory responses linked to cardiovascular disease.MALAT1is decreased in preeclampsia placentas and may have a cis-regulatory function on neighboring RNAs.METHODS:Expression ofMALAT1,NEAT1,mascRNA,SCYL1, andFRMD8was assessed in peripheral blood mononuclear cells, andMALAT1in plasma and extracellular vesicles, at 22 to 24 and 36 to 38 weeks of gestation in healthy (n=214) and preeclampsia (n=37) women from the STORK cohort study (STORe barn og Komplikasjoner, translated as Large Babies and Complications) and at 5-year follow-up in women with and without history of preeclampsia (n=29; n=271). We investigated their associations with established markers of disease activity and later cardiometabolic risk.MA