MYDGF beschermt de endotheelfunctie bij hypertensie

BACKGROUND:Endothelial dysfunction is recognized as a crucial initiating factor for hypertension and associated cardiovascular/renal injury. Although MYDGF (myeloid-derived growth factor) is mainly derived from bone marrow cells, recent studies have also found the expression of MYDGF in different parenchymal cells. However, the expression pattern and the role of endothelial MYDGF in hypertension remain unclear.METHODS:Endothelial-specific knockout ofMYDGFmice and recombinant MYDGF were used to examine the role of MYDGF in hypertension and associated cardiovascular/renal injury.RESULTS:Endothelial MYDGF was significantly downregulated in hypertensive mice.MYDGFdeficiency in the endothelium aggravated endothelial dysfunction and cardiovascular/renal injury in hypertensive mice, which was attenuated by the overexpression of MYDGF or recombinant MYDGF. Functionally, MYDGF maintained endothelial homeostasis via pleiotropic protective effects, including anti-inflammation, antiapoptosis, inhi