Bloeddruk 'time in target range' voorspelt sterfte bij hypertensie

BACKGROUND:Time in target range (TTR) reflects the proportion of time blood pressure (BP) remains within a defined range, integrating BP variability and control. We examined associations of systolic BP (SBP) TTR during ambulatory BP monitoring with cardiovascular and all-cause mortalities.METHODS:Patients from the Spanish Ambulatory BP Monitoring Registry who were receiving antihypertensive medications or who had sustained or masked hypertension without treatment, defined by office BP ≥140/90 mm Hg and 24-hour BP ≥130/80 mm Hg. TTR was estimated by linear interpolation between consecutive SBP recordings obtained from ambulatory BP monitoring and expressed as the proportion of time SBP remained within 120 to 134 mm Hg during daytime and 110 to 119 mm Hg during nighttime, from which 24-hour TTR was derived. Associations with mortality were assessed by Cox regression adjusted for demographic and clinical variables.RESULTS:A total of 48 687 patients (46% women) were analyzed. Over a median