Pathologische diagnostiek met moleculaire monitoring bij nierxenotransplantatie

Kidney xenotransplantation addresses organ shortages; however, short-term clinical observations provide limited insights into long-term graft changes. A pathology–molecular framework integrating biopsy phenotyping, transcript analysis, and spatial profiling can improve the interpretation of long-surviving pig-to-nonhuman primate kidney xenografts. B-HOTX, a xenograft-adapted version of the Banff Human Organ Transplant gene panel, distinguishes donor from recipient transcripts, reducing the misclassification of physiological leukocyte signals as rejection.