Cellulaire senescentie als therapeutisch doelwit bij diabetische nierziekte

Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease globally. Although modern treatments can slow the progression of DKD, a substantial number of individuals still advance to kidney failure each year, attributed to complex, multifactorial pathophysiological processes that confer treatment resistance. Cellular senescence, an irreversible state of cell cycle arrest, has emerged as a recognized driver of DKD pathogenesis, which propagates chronic inflammation, leading to tissue damage.