Reactie op kanttekeningen bij statistiek van orale microbioomdiversiteit en mortaliteit

We appreciate Dr. Yang Shen and Dr. Weijie Hu for their interest in our research, “Oral microbiome alpha diversity and all-cause, cardiovascular, and non-cardiovascular mortality in US adults: Evidence from the NHANES 2009–2019”, published in Atherosclerosis [1]. In their letter [2], the authors argued that omission of National Health and Nutrition Examination Survey (NHANES) Sampling Weights in our statistical analysis, i.e., unweighted survival analyses using Cox regression models, may lead to biased results, in terms of ensuring nationally representative estimates from NHANES that employed a complex, stratified, multistage probability sampling design.