Aldosteron en de mineralocorticoïdreceptor bij atriumfibrilleren

Atrial fibrillation represents the most prevalent cardiac arrhythmia and is associated with substantial morbidity, including an increased risk for stroke and heart failure. The pathophysiology of atrial fibrillation involves electrical and structural remodeling of the atria, often referred to as atrial myopathy, that together increase the risk for arrhythmias. However, a specific approach to target the proarrhythmic substrate of atrial fibrillation is still lacking. Aldosterone and the mineralocorticoid receptor are well-known drivers of cardiac remodeling, and recent clinical and experimental studies indicate that they play a critical role in the pathogenesis of atrial fibrillation. Elevated aldosterone levels, for example, in primary aldosteronism, are associated with a higher risk for atrial fibrillation. Mineralocorticoid receptor antagonists reduce the onset of atrial fibrillation across various patient populations, including patients with hypertension, heart failure, chronic kidn